�Ardea Biosciences, Inc.
(Nasdaq: RDEA) announced that the Medicines and Healthcare products
Regulatory Agency (MHRA) in the United Kingdom has authorized a Phase 1
study evaluating RDEA594 in normal respectable volunteers. RDEA594 is the
Company's tether product candidate for the treatment of gout.
"Regulatory clearance for us to proceed with our Phase 1 work of
RDEA594, within sise months from designation as a clinical candidate is a
testament to the efficiency of our development organization, and the
importance we station on our gout political platform -- a program we intend to expand
with second-generation compounds from our exciting ongoing research in this
region," said Barry D. Quart, PharmD, Ardea Biosciences' President and CEO.
"Earlier this quarter, we initiated a Phase 2a proof-of-concept cogitation of
RDEA806, a prodrug of RDEA594, which should allow us to provide an early
confirmation of RDEA594's activeness in the target population of patients
with gouty arthritis."
This Phase 1, randomized, double-blind, placebo-controlled trial will
evaluate the safety, tolerability, pharmacokinetics and uric acidulent lowering
effects of single ascending oral doses of RDEA594 in healthy grownup male
volunteers.
About Gout
An estimated xxxv million people in the United States, and close to
5 1000000 people in the European Union, suffer from gout, which is the to the highest degree
common form of inflammatory arthritis in men over 40. Gout, also known as
metabolous arthritis, is a painful and debilitating disease caused by
abnormally elevated levels of uric acid in the blood stream. These
abnormally lofty levels lead to the deposition of uric acidic crystals in
and around the connexion tissue of the joints and in the kidneys, leading
to inflammation, the formation of disfiguring nodules (tophi), intermittent
attacks of severe hurting (acute flares), and kidney damage (nephropathy).
While gout is a treatable condition, there are limited treatment options
and a number of adverse effects are associated with current therapies. No
new therapies get been approved by the FDA for the handling of
hyperuricemia associated with gout in the past 40 years
About RDEA594
RDEA594, our booster cable product candidate for the treatment of gout, is a
major metabolite of RDEA806, our lead non-nucleoside reverse transcriptase
inhibitor (NNRTI) in clinical development for the discourse of HIV. RDEA594
does not have antiviral action and is believed to be creditworthy for the
uric acid-lowering effects discovered following establishment of RDEA806 to
over 100 subjects in Phase 1 and Phase 2 clinical trials. In Phase 1
studies of RDEA806 in normal healthy volunteers, increased urinary
excretion of uric vitriolic was ascertained in the first 24 hours after dosing,
with statistically significant, exposure-dependent, decreases in serum uric
acidic of 35% to 50% observed during multiple dosing out to 14 days.
About RDEA806
RDEA806 is a novel NNRTI for the potential intervention of HIV infection.
Based on preclinical and clinical studies to date, we believe that RDEA806
may have important competitive advantages compared to currently useable
NNRTIs. These include the potential for potent antiviral drug activity against a
wide-eyed range of HIV viral isolates, including those that are resistant to
efavirenz (Sustiva(R)) and other currently available NNRTIs; a senior high genetic
barrier to resistance; limited pharmacokinetic interactions with other
drugs; no reproductive toxicity based on fauna studies; and the potency
to be readily co-formulated in a single pill with other HIV antiviral
drugs, such as Truvada(R) (emtricitabine and tenofovir) from Gilead
Sciences, Inc, which is of import for patient compliance.
About Ardea Biosciences, Inc.
Ardea Biosciences, Inc., of San Diego, California, is a biotech
company focussed on the discovery and development of small-molecule
therapeutics for the treatment of HIV, urarthritis, cancer and inflammatory
diseases. We suffer five merchandise candidates in clinical trials and others in
preclinical development and discovery. Our most advanced product prospect
is RDEA806, an NNRTI, which has successfully completed a Phase 2a study for
the treatment of patients with HIV. We have evaluated our second-generation
NNRTI for the discourse of HIV, RDEA427, in a human micro-dose
pharmacokinetic study and have selected it for clinical development.
RDEA594, our lead mathematical product candidate for the discourse of gout, is organism
evaluated in a Phase 1 study. We ar currently evaluating our lead MEK
inhibitor, RDEA119, in a Phase 1 study in advanced cancer patients, and
make completed a Phase 1 study in normal good for you volunteers as a forerunner
to trials in patients with incitive diseases. Lastly, we get evaluated
our second-generation MEK inhibitor for the treatment of cancer and
inflammatory diseases, RDEA436, in a human micro-dose pharmacokinetic study
and have selected it for clinical development.
Statements contained in this press release regarding matters that are
not historical facts are "forward-looking statements" within the signification of
the Private Securities Litigation Reform Act of 1995. Because such
statements are theme to risks and uncertainties, actual results may
dissent materially from those explicit or implied by such forward-looking
statements. Such statements include, but are not limited to, statements
regarding our goals, including the expected properties and benefits of
RDEA806, RDEA427, RDEA594, RDEA119, RDEA436 and our other compounds and the
results of preclinical, clinical and other studies. Risks that contribute
to the uncertain nature of the forward-looking statements include: risks
related to the issue of preclinical and clinical studies, risks related
to regulatory approvals, delays in commencement of preclinical and clinical
studies, and costs associated with our do drugs discovery and development
programs and business development activities. These and other risks and
uncertainties are described more fully in our most lately filed SEC
documents, including our Annual Report on Form 10-K and our Quarterly
Reports on Form 10-Q, under the headings "Risk Factors." All
forward-looking statements contained in this press release speak only as of
the date on which they were made. We undertake no obligation to update such
statements to reflect events that occur or circumstances that be after
the date on which they were made.
Ardea Biosciences, Inc.
http://www.ardeabio.com
View drug information on Sustiva.
More information
Wednesday, 3 September 2008
Thursday, 14 August 2008
Jay Leno To Scarlett Johansson: 'Have Sex In My Car'
...more Scarlett Johansson �
Jay Leno made Scarlett Johansson an unusual offer on his shew last workweek � The chance to live out her sexual fantasy of getting down and marked-up in a car.
The chat show host made Scarlett recount what she told women�s magazine publisher Cosmopolitan when she appeared on the cover.
The Vicky Christina Barcelona actress explained: "Somebody asked me ane time what my sexual fantasy would be and under the guise of sounding gaga I aforementioned it would be having sex in a elevator car. But that seemed genial of cautious to me afterwards."
And Leno - world Health Organization boasts a massive collection of antique cars - took to the entrance money by offering one of his vehicles for Johansson's sexual escapades.
But the astonished actress was quick to reject the offer, shouting back at the host: "Jesus Christ... what is going on?"
Leno had better watch his back, Ryan Reynolds whitethorn soon be after him...
Wednesday, 6 August 2008
John Surman, Karin Krog, Terje Rypdal, Vigleik Sto
Artist: John Surman, Karin Krog, Terje Rypdal, Vigleik Sto
Genre(s):
Avantgarde
Avantgarde
Discography:
Nordic Quartet
Year: 1995
Tracks: 9
Les Baxter
Friday, 27 June 2008
Bollea Calls For Hogan To Be Locked Up
Hulk Hogan's estranged wife Linda Bollea has filed an emergency court motion asking a Florida judge to throw the wrestling legend in jail - for failing to pay her the agreed $4.2 million (?2.1 million) to buy an apartment in Las Vegas. The pair has been embroiled in a bitter war of words since Linda filed for divorce from Hogan - real name Terry Bollea - last November after 23 years of marriage. At a hearing in April , Hogan was ordered to hand over the cash to Linda to finalise the buy, which they had been in the process of purchasing when he was hit with divorce papers. The judge ruled Hogan must pay to complete the deal, after which the condominium would be considered a shared asset. The division of assets is to be decided at a later date. However, according to legal documents filed on 2 June and obtained by website Tmz.com, Linda claims Hogan is in contempt of court because he has still not paid for the pad. And she wants him locked up - in the same jail where their 17-year-old son Nick is currently serving his eight-month sentence for felony reckless driving charges. In the papers, Linda's attorneys urge the court to: "Find the Husband (Hogan) in willful civil contempt of Court for his failure to comply with the terms of the Court's Order Approving Stipulation as to Las Vegas Condominium Contract and for Related Matters." They also call for the judge to: "Incarcerate the Husband in the Pinellas County Jail until he performs all necessary acts required by the existing Court Order, including providing the necessary funds to the Closing Agent and obtaining title to the aforementioned real property in joint names of the Husband and the Wife (Linda)."
See Also
See Also
Thursday, 19 June 2008
Denise: "I'm Done with Charlie"
While Charlie Sheen has promised to no longer speak about his estranged ex Denise Richards to the press, the actress has clearly not taken the same vow.
"I'm done with Charlie," she tells AOL. "I'm at a point where I'm sick of it, and now I'll just talk because I've had three years of this. It's crazy."
"Crazy" is all the "lies" the actor puts out there about her, trying to paint in her in a negative light, Denise says. Some of his untruths? That she wanted to crash his wedding to Brooke Mueller, requested an early copy of his OK! wedding cover story, received $40 million in their divorce and asked him for his sperm.
"All of that is garbage," she says. "He needs to shut up. He talks about me exploiting the kids, but he's exploiting our entire situation in the public."
Although Charlie's remarried, Denise is not looking for a new relationship yet despite the fact that the series premiere of her reality show Denise Richards: It's Complicated showed her going on a date.
"I've been through hell," she says. On top of everything else, I lost my mother over the holidays. I'm not looking for a relationship. If one happens to come along, fantastic. But I'm fine just focusing on being with my girls and working and getting things more settled."
And perhaps another Playboy spread is in the cards as well.
"It's still a possibility. It's so iconic and fun. I think that my niche is as a sex symbol. I'm never going to be the girl next door, so why not play up my niche?"
See Also
Wednesday, 11 June 2008
Angelina Jolie - The Things They Say 8471
"It's not the politically correct thing to say, but to jump around with guns - it's always fun. Really I'm just a big kid." Actress ANGELINA JOLIE explains her love of action films.
See Also
Thursday, 5 June 2008
Tuesday, 27 May 2008
Mourning September
Artist: Mourning September
Genre(s):
Other
Discography:
A Man Can Change His Stars
Year: 2004
Tracks: 10
Monday, 19 May 2008
Blue Tonic World
Artist: Blue Tonic World
Genre(s):
Ambient
Discography:
The Deepest Blue Album
Year: 2000
Tracks: 12
Enter The Light
Year: 1999
Tracks: 11
Saturday, 10 May 2008
Watson thought he was going to die
Watson thought he was going to die
Opera isaac M. Singer Russell James Watson has revealed that he didn't call up he was "going away to gain it" afterwards organism rushed to infirmary to let a lifesaving brain operation.
Speech production on 'GMTV', the isaac Merrit Singer said that doctors told him that it was "reach and go" when he was taken into infirmary to cause a tumor removed from his brain.
Watson said: "I commemorate cerebration 'Oh honey, I don't consider I'm going to make it this time'."
The vocalizer was number one struck fine-tune with the tumour stopping point year and underwent an operation to remove it but scans later on revealed that the neoplasm had grown back.
Thomas Augustus Watson said: "It was real scary. My vision had gone, and basically when I was rushed into hospital I was really, very ill and, there was no inquiry, the doctors told me when I arrived it was touch and go."
"I wasn't truly that aware of what was going on anyway. I was flitting in and come out of the closet of consciousness. I remember hearing loads of medical checkup people saying speech like 'haemorrhage' and oodles of very scary things," he said.
Deutschland sucht den Superstar
Connolly to star in X-Files movie
Connolly to star in X-Files movie
Scots comic Billy Little Mo Connolly is to star in the irregular 'X-Files' motion picture, according to reports.
He will join doorknocker Xzibit and 'The Whole Nine Yards' headliner Amanda Peet in the latest picture version of the hit sci-fi TV show, according to The Hollywood Newsperson.
Details of the trio's roles have non been released, all the same it is understood that Xzibit and Peet volition play Federal Bureau of Investigation agents working with Mulder (David Duchovny) and Scully (Gillian Anderson).
The flick testament be directed by series creator Chris Carter and is a stand-alone feature rather than a continuation to the first 'X-Files' photographic film, released in 1998.
Little Mo Connolly previously starred in 'Mrs Brown', 'Lemony Snicket's A Series of Unfortunate Events' and 'The Shoemaker's last Samurai', while Xzibit appeared in '8 Mile' and MTV's 'Pimp My Ride'.
The cinema is due for release on 25 July, 2008.
Celebrity Hijack nominations announced
Celebrity Hijack nominations announced
Emilia, Jeremy, Victor and Liam have all been chosen to face the 'Big Brother: Fame Hijack' public dispossession ballot this calendar week.
Two of the four will be evicted tomorrow night in a surprise double-eviction on the live evidence.
Celebrity hijacker Joan Rivers chose wHO would face the public vote after hearing to the housemates' reasons for wanting other hoi polloi out.
Antonius and Amy were guaranteed unsusceptibility from the public vote afterwards they won a task earlier in the week, while Bathroom antecedently north Korean won a place in the final of the evince.
For more on 'Big Brother: Celebrity Hijack' read our web log here.
Buble's Blunt about love
Buble's Blunt about love
AS Australia's A-list gears up for the Logie Awards at Crest this eventide, on the other side of the world vocaliser Michael Buble crataegus laevigata well be intuitive feeling a sting of nostalgia.
Backstage at the ceremony trey old age ago, spell here promoting his second album It's Clip, the Canadian crooner met mortal very special.
"It's where I number one laid eyes on the incredibly gorgeous Cast McManus," Buble says, absolutely deadpan from a hotel room in Capital of Colorado, Colorado River. "And there's a sexual tension on that point, of course. Well, from single way -- me to him."
Another quite to a greater extent radiant headliner also caught his eye that night. Then for the most part stranger Brits actor Emily Benumb was also in Melbourne promoting her film My Summertime of Love and Buble was smitten.
"It was sort of love at first-class honours degree sight, just for a long time I thought it was puppy love," he says. "Simply it wasn't. It was lovemaking.
"I had no clew she was an actor and now to think that I am sitting alone in a hotel room talk to you and she is making out with Benicio Del Toro (co-star of her coming pic The Wildcat Military personnel), I got absolutely screwed in the manage."
Trey long time later, the couple are still together, that is whenever their occupy schedules will permit. Blunt is now i of the hottest stars round thanks to scene-stealing turns in The Devil Wears Prada and Charlie Wilson's Warfare and Buble's dance menu has never been fuller, especially now the US has succumbed to his charms.
Buble admits "it's ludicrously yob to have this kind of relationship", but the down-to-earth Canadian says the ability non to film each other besides earnestly is the florida key.
Whatever, it is has worked, with the couple still surviving a love-rat malicious gossip cobbler's last year when a woman told a newsprint she had been litter the vocalizer for a decade. Buble has never responded to the claims and under no lot is he going to. He prefers to keep a low profile on the relationship front, finding the mind of the famous person couple shoal and repellant.
"I'm non departure to call names, only there ar just excessively many celebrity couples come out there wHO I just want to pink out," he says.
"It's whole 'schmoopie woopie, we are so famous and wealthy and we ar so happy. Graven image we are happy'. And there's me posing at home with my catgut dangling out and nachos on my underclothes thought process, 'F--- off'."
Buble is climax to the end of a gruelling, but successful sports stadium spell of the US with his crack 13-piece band and and so will have a duo of weeks away before heading Down Below for his third gear tour.
Commonwealth of Australia was the offset state outside his country of origin to embrace Buble's trickily chosen collection of jazz standards and swinging versions of contemporary songs, sending his self-titled debut to No.1 in 2003. The lovemaking affair continued for his secondment album and his most holocene epoch endeavour, Call off Me Irresponsible, was the highest-selling album in this country end year.
European Economic Community and Great Britain besides fell under his vacillation spell, only the US took thirster to crock up. The hard work and constant touring paid off when he was rewarded with his first US No.1 as well as the 2008 Best Traditional Pop Vocal Record album Grammy Award for Call Me Irresponsible. The success was whole the sweeter in that it proved his doubters wrong.
"I was signed by Charles Dudley Warner Brothers in America," he says. "And in that location were a lot of people world Health Organization believed in me, simply on that point were a draw of people wHO didn't.
"In that location is a guy cable in the troupe world Health Organization, i day at a party, I overheard locution, 'Why did we augury this Francis Albert Sinatra shave?' So it's kind of a cool down thing to be the underdog. I will never say anything to the guy wHO said that -- only at the lapplander time I get it in the back of my psyche that the Sinatra glom was the highest-selling recording creative person with that company."
Like his idol Hot dog Francis Albert Sinatra, Buble's claim to fame has been as an translator of other people's songs -- whether it be classics such as Summertime Wind or Come Fly With Me or screening to a greater extent coeval artists such as Elmore John Leonard Cohen, Eric Clapton and even Queen. He still regards that as his strong suit, just to a greater extent lately the focus has been on his have songs; he wrote iI of the tracks on his last album, both of which were released as singles. Lost was written subsequently the split up with his former fiancee, Debbie Timuss, and Everything is his loved-up tribute to the multi-talented Blunt, wHO also panax quinquefolius backing vocals on his version of Me And Mrs John Paul Jones.
There will be to a greater extent to descend on his next album likewise, having teamed up with songwriter-for-hire extraordinaire Kara DioGuardi (Christina Aguilera, Kylie Minogue, Gwen Stefani) as well as his regular collaborators.
Writing his own material besides has a practical side -- he gets played on pop radio stations of the Cross that wouldn't touch a jazz touchstone with a 10-foot pole.
Buble says that contrary to popular perception, he finds it easier to compose his possess music than re-explain that of others.
"People assume that you lavatory require a monetary standard and sing it over again -- it's not soft," he says.
"For the most region I am pickings these songs and conceptually giving them a brand-new life and feel. That takes a destiny of work and stirring as well as beautiful arrangements and great product and musicianship.
"Let's say I cover a strain like That's Life or Wonderful Tonight. The instant it comes out, people compare it. Is it as commodity as Sinatra's reading or Clapton's version or Dean Martin's adaptation or (Bobby) Darin's version or (Ella) Fitzgerald's adaptation or (Mel) Torme's variation? To form your adaptation stand come out it had punter be interesting and have some originality. With one of my pilot songs -- world Health Organization the hell ar they exit to compare it to?"
The Vancouver native last month added to his trophy cabinet at his home country's medicine awards, the Junos, by pickings out the Fan Selection Award. His strain Everything was beaten in the One of the Year category by 1234, sung dynasty by uprising indie star Fice.
At the time he joked: "It was a great award to get this award from the fans. But I had a painful night the other night because I just kept boot the sh-- come out of myself for not writing 1234."
He is surprised to get word the song was co-written by an Australian, Melbourne singer/songwriter Crack Seltmann.
'You are kidding me," he says. "Something weird, actually, the sung dynasty Doomed was written in Melbourne at the Como Hotel. I got hammered likewise -- I was come out of the closet of it, I can't consider I was able to come up with that."
Michael Buble's Rod cell Red laver Arena shows on June 6, 7, 18 are sold out. Tickets are still available to the June 19 show on 132 849. Call Me Irresponsible is out now.
To deliver the goods two tickets to the June 19 prove, visit heraldsun.com.au/lifestyle/competitions ahead twelve noon on Th. Winners drawn at noonday on Fri and notified.
Far-Less
Lisa Marie Presley Accepts Tabloid's Apology
Lisa Marie Presley Accepts Tabloid's Apology
Lisa Marie Elvis Presley has reluctantly accepted an excuse from a British people rag, later on they ran a chronicle claiming "Bloated Lisa Marie is now the double of pappa Elvis", forcing her to let on her maternity.The story made headlines worldwide when The Day by day Mail ran photos of Elvis Presley feeding lunch in Los Angeles."After existence the mark whole week of slanderous and degrading stories, awfully manipulated pictures and articles in the media," she wrote at the clip. "I have had to show up my card game and announce below the gun and under vicious personal attacks that I am in fact pregnant." The Daily Mail service printed an apology last Fri locution:"On MArch 4, we published a shoot of Lisa Marie Elvis Presley patch she was dining with friends. We suggested she might have an unhealthy appetence similar to her deep don. We now accept that the suggestion is untrue and apologise to Ms Presley for any distress caused." Elvis Aron Presley responded via her official MySpace on Sunday (Crataegus oxycantha 4) stating, "It never ceases to amaze me how hard it is to get an apologia and when you finally do it is Never in the saami linguistic context or magnitude as the archetype slanderous tale. Disregardless, I accept their attack at buyback."The daughter of Lucy in the sky with diamonds as well says that any finances that come from the settlement "will go straight off into the Presley Charitable Initiation... I catch immense pleasure out of making something good come from something badly."Photo good manners of MySpace.
Subscribe to:
Posts (Atom)